THQ revealed the complete roster for the game. The key is as follows: LH - Can also be used as light heavyweight, MW - Can also be used as middleweight, WW - Can also be used as welterweight, LW - Can also be used as lightweight, DLC - Available through downloadable content.
Antonio Rodrigo Nogueira, Brock Lesnar, Frank Mir, Brandon Vera (LH), Gabriel Gonzaga, Cain Velasquez, Cheick Kongo, Eddie Sanchez, Heath Herring, Andrei Arlovski, Mirko Crocop, Fabricio Werdum, Tim Sylvia, Mark Coleman, Antoni Hardonk, Justin McCully
Chuck Lidell, Quinton "Rampage" Jackson, Forrest Griffin, Tito Ortiz, Keith Jardine, Wanderlei Silva, Mauricio "Shogun" Rua, Lyoto Machida, Rashad Evans, Stephan Bonnar, James Irvin, Wilson Gouveia (MW), Houston Alexander, Kazuhiro Nakamura, Thiago Silva, Tim Boetsch, Ryan Bader (DLC)
Anderson Silva (LH), Rich Franklin (LH), Dan Henderson (LH), Michael Bisping (LH), Kendall Grove, Chris Leben, Jason MacDonald, Nate Marquardt, Drew McFedries, Ricardo Almeida, Evan Tanner, Yushin Okami, Demian Maia, Martin Kampmann (WW), Amir Sadollah (WW), Thales Leites
Georges St-Pierre, Matt Hughes, Matt Sera (LW), Jon Fitch, Karo Parisyan, Josh Koscheck, Diego Sanchez, Mike Swick (MW), Marcus Davis, Thiago Alves, Chris Lytle, Ben Saunders, Josh Burkman, Kyle Bradley, Matt Arroyo, Anthony Johnson
BJ Penn (WW), Sean Sherk (WW), Kenny Florian, Roger Huerta, Joe Stevenson, Mac Danzig, Nathan Diaz, Spencer Fisher, Tyson Griffin, Gray Maynard, Thiago Tavares, Joe Lauzon, Rich Clementi, Mark Bocek, Hermes Franca, Frank Edgar, Efrain Escudero (DLC)